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課程名稱 |
結構生物學與生物資訊特論
Structural Biology & Bioninformatics |
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開課學期 |
104-1 |
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授課對象 |
生命科學院 基因體與系統生物學學位學程 |
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授課教師 |
楊啟伸 |
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課號 |
Biot8003 |
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課程識別碼 |
642ED0040 |
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班次 |
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學分 |
3 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期五6,7,8(13:20~16:20) |
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上課地點 |
生技館212 |
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備註 |
本課程以英語授課。與蔡孟勳合開
限博士班
總人數上限：20人
外系人數限制：15人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1041Biot8003_sbinfo |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
This is a class integrates the concepts of structural biology and bioinformatics. The basic principle of amino acids and structre will be explained first, then the modern methods to resolve atomic resolution of protein structures. The relation of protein structure and function will be emphasized in the third part of this class. Bioinformatic principles, methods and modern developments will be followed. |
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課程目標 |
1. Understand amino acids and protein structures.
2. Modern approaches to resolve protein structure.
3. Protein structure and function.
4. Software-based analysis of protein sequence.
5. Bioinformatic theories
6. Current developments of bioinformatics methods. |
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課程要求 |
This class will be taught in English. |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
1. David Whitford (2005). Proteins : Structure and Function. John Wiley & Sons, Hoboken, NJ. USA.
2. Gregory A. Petsko and Dagmar Ringe (2003). Protein Structure and Function, 4th ed., New Science Press, Waltham, MA.
3. Materials are updated when new developments occur. |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
Mid-term |
30% |
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2. |
Final exam |
50% |
Bioinformatic part could composed of presentation, too. |
3. |
Presentation |
20% |
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週次 |
日期 |
單元主題 |
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第1週 |
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1. Concepts of structural biology
2. Software tools for structural biology |
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第2週 |
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1. Basic protein structure
2. Amino acids and structure |
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第3週 |
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Protein Structure and Functions |
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第4週 |
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Happy Birthday, Taiwan! |
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第5週 |
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Protein functional domain and motif |
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第6週 |
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Modern methods resolving protein structure |
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第7週 |
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BYOC: Bring your own computer; Let's do animation!
Life science and structural biology: Cellular functions, Membrane proteins |
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第8週 |
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Life science and structural biology (2): G-protein system and two components system in <i> E. coli</i>
Show time: Your presentation! |
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第9週 |
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Midterm Exam |
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第11週 |
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Introduction of bioinformatics |
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第12週 |
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Genomic analysis: NGS introduction |
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第13週 |
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Transcriptome: Microarray introduction (1) |
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第14週 |
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Microarry (2): Data analysis |
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第15週 |
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NTUMAPs demostration |
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第16週 |
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Genetic and population analysis: SNP introduction |
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第17週 |
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DNA copy number variation |
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